Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers and stabilizers. Immunofluorescence evaluations showed that each compound initially caused microtubule depolymerization and, surprisingly, with highe...

ENANO n4 ULTIMO.qxd

Movable (n4) Configurations

An (nk) configuration is a collection of points and straight lines, usually in the Euclidean plane, so that each point lies on k lines and each line passes through k points; such a configuration will be called symmetric if it possesses non-trivial geometric symmetry. Although examples of symmetric (n3) configurations with continuous parameters are known, to this point, all known connected infin...

Antileishmanial Activity of a Series of N2,N4-Disubstituted Quinazoline-2,4-diamines

A series of N(2),N(4)-disubstituted quinazoline-2,4-diamines has been synthesized and tested against Leishmania donovani and L. amazonensis intracellular amastigotes. A structure-activity and structure-property relationship study was conducted in part using the Topliss operational scheme to identify new lead compounds. This study led to the identification of quinazolines with EC50 values in the...

Priestley duality for N4-lattices

We present a new Priestley-style topological duality for bounded N4-lattices, which are the algebraic counterpart of paraconsistent Nelson logic. Our duality differs from the existing one, due to Odintsov, in that we only rely on Esakia duality for Heyting algebras and not on the duality for De Morgan algebras of Cornish and Fowler. A major advantage of our approach is that for our topological ...